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Holmes and Rahe (1967)
Holmes and Rahe when investigating the causes and sources of stress focused on stressors and tried to identify the characteristics of a situation that makes it stressful. This is often called the stressful life event approach or the engineering model.
An interesting Observation suggested a relationship between the social readjustment scale and subsequent health. For example, Holmes and Rahe observed that people who scored between 200 and 300 points in a given year were statistically likely to develop health problems the following year; and those who had scored over 400 points were likely to suffer a major illness. The researchers suggested that this came from the physical drain on the body produced by the continual Arousal and the general adaptation to long-term or repeated stress.
Holmes, T.H. & Rahe, R.H. (1967). The social readjustment rating scale. Journal of Psychosomatic Research, 11, 213-218



